Vaccines Scientific Leaders Programme 2020 Italy – Preclinical R&D (B cells)
GSK
Siena, Siena, Italy,
3 gg fa

Are you a brilliant scientist? Do you want to join a world-leading Research & Development Vaccines environment, and help build its future?

This is an exciting opportunity to channel your passion for science to help shape the future of the Vaccines function and revolutionise the way in which GSK conducts its R&D in the future.

Do you want to be part of a company investing in scientific and technical excellence to develop a pipeline of new products to meet the needs of patients across world?

About Vaccine R&D

As vaccine development has advanced, new types of vaccines have arisen, presenting challenges in characterization and further linking characteristics to function.

However, recent development of vaccines against current pandemics or more complex diseases such as has met difficulties.

In addition, the gaps in our knowledge on protective responses against pathogens are a significant barrier to ideal vaccine design and are often associated with increased risk of clinical failure.

What is Vaccines Scientific Leaders Programme?

The Scientific Leaders Programme in Vaccines is a 2-year global programme which builds a pipeline of scientists with the right expertise, technical capabilities and behaviours to drive the future in Vaccines Research and Development.

How does the Vaccines Scientific leaders Programme work?

You will spend two years working on a key development project, contributing to key strategic areas of our Vaccines R&D business.

We have three location options; Italy, Belgium or US which aligns to our Vaccine R&D hubs. Working on challenging projects will provide you with in-depth knowledge of the ways in which Science and Technology is being applied across R&D in GSK.

All associates will be contributing to our mission to improve the quality of human life, by enabling people to do more, feel better and live longer all while fostering strong foundations for a future career in science.

Is the Vaccines Scientific leaders Programme for you?

This is a scientific / technical leadership position where you will be empowered to be innovative, collaborative, decisive and bold to solve novel R&D problems.

On completion of the 2-year programme we aim to bring you on-board into available technical leadership roles that best suits business’ needs and your abilities.

We need Scientific leaders to help embed modern Scientific principles and ways of working within the vaccines R&D organisation.

You will do this through :

Project Title : Exploitation of state of the art capabilities for investigating circulating monoclonal antibodies and B cell repertoires after vaccinations with multivalent formulations

Project proposal : Analysis of humoral response to vaccination remains a challenging task. Although next-generation sequencing of immunoglobulin gene repertoires (IgG-seq) allows the investigation of large-scale antibody dynamics at a sequence level, this information does not necessarily reflect the complexity of the circulating IgG.

Moreover, it is difficult to determine if immunodominance, a crucial attribute of antibody binding capability in complex antibody populations, is collected in IgG-seq protocols.

The aim of the project is to investigate how much of the peripheral antibody diversity is represented by peripheral B cells.

Aim : Investigate the diversity of antigen-specific serum antibodies and B cell repertoires in vaccinated individuals and in convalescent patients, by setting of a proteomics platform to analyse humoral responses in comparison to DNA sequencing analysis of B cell repertoire.

The approach could be applied to active vaccination projects under development to charaterise responses to vaccine formulations, as well as to support attempts to select therapeutic mAbs and guide antigen design.

Expected outcome :

  • 1 : understand if the peripheral antibody diversity is represented by B cell repertoires
  • 2 : assess immuno-dominance in polyclonal antibody responses in individuals.
  • 3 - identify differences and common themes between individuals
  • 4 - identify differences and common themes between vaccinated and convalescent patients
  • To be successful in this role you should have :

  • PhD in Protein Biochemistry or Proteomics
  • Strong experience in complex proteomics with a good knowledge in bio-informatics.
  • Experience in HDx- MS (preferred).
  • High capability to adapt in areas out of the major field of expertise (preferred).
  • Excellent written and verbal communication skills.
  • The ability to deal with complexity, and strong problem-solving and self-directional abilities.
  • Excellent interpersonal skills & ability to explain complicated subjects to non-expert audiences.
  • English is mandatory. Knowledge of Italian is a plus
  • The program will include exciting and impactful projects for each candidate, with an emphasis of developing the deep technical expertise within Preclinical R&D and the other (depending on the candidate’s skillset) with partner organisations, with whom we will partner with to deliver these initiatives.

    Available Location : Italy Siena

    Applications will close on Friday the 21st of August 2020

  • LI-GSK
  • If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

    GSK is an Equal Opportunity / Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity / expression, age, disability, genetic information, military service, covered / protected veteran status or any other federal, state or local protected class.

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