Principal Investigator Discovery Research
Axxam
Bresso, Italy
5 gg fa
source : Experteer

Axxam is a leading provider of integrated discovery services for the entire Life Sciences industries such as Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition.

We have world-class expertise across a broad range of discovery disciplines and innovative technologies including : assay development, compound management, high throughput screening, hit identification and hit validation.

Axxam is also engaged in developing strategic partnerships aimed at generating novel innovative therapies for diseases with high unmet medical need.

An open and dynamic working environment ensures high-quality results from the teams of scientists and other professionals conducting all the experimental activities, supported by an industrialized organization.

Principal Investigator Discovery ResearchWe are currently seeking a Project Leader (Principal Investigator) for the Discovery Group experienced in hit identification and lead generation to drive our proprietary discovery projects.

RESPONSIBILITIES : In cooperation with the Director of Discovery Research, and Program Manager, defines deliverables, project plan, timelines and budget for the discovery projects.

Defines the outsourcing plan and identifies appropriate CROs or academic collaborators, negotiating costs and timelines;Manages the development and execution of the project plansAddresses or reports conflicts and project constraintsSupervise objectives connected with laboratory experimentsPlans, schedules and tracks progress to project milestonesEnsures information and decisions are clearly communicated, documented and archived.

Maintains project core files.The successful candidate will be familiar with the early steps of the drug discovery process, including : functional in vitro assay generation, HTS, hit validation and the full range of hit to lead activities.

He / she will coordinate all laboratory activities necessary to identify and then optimise new bioactive small molecules against a defined target as potential new drugs, in collaboration with Axxam biologists, chemists and external collaborators.

Moreover he / she will actively monitor the scientific literature on the targets and therapeutic areas of interest and the competitive landscape.

The successful candidate will have a strong scientific and technical background, together with proven experience in successful early drug discovery projects in an industrial environment.

The position will require the ability to work with multidisciplinary and international teams and strong communication skills with both internal and external partners.

  • QUALIFICATION & SKILLS : A Ph.D. in cell biology, pharmacology or related discipline is strongly preferred.Familiarity with basic pharmacological concepts for receptors, ion channels, enzymes and transportersFamiliarity with drug discovery in the area of CNS diseases would be strongly preferredHit to Lead process including basic concepts of medicinal chemistry and in vivo pharmacokinetic studiesFluent spoken and written EnglishSelf-motivated and organisedExcellent team playerAbility to set and work within defined deadlines and budgetExcellent analytical skills;
  • ability to address technical challenges- ability to process and analyze complex results and data setsExcellent interpersonal skills, ability to develop productive relationships with multiple and different parties, including scientists, scientific institutions representatives, good conflict management skillsProficient in Microsoft Office programs (Excel, Word, PowerPoint).
  • Axxam is an equal opportunity employerAxxam offers a stimulating work environment and a competitive salary.If your background and personal experience fit this profile, please send your complete application, including a brief description of your experience, your CV and a list of references.

    Sede di lavoro : Bresso,MI(Italy)

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